Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules

The primary reason for adding TMG when using NMN or NR is because they increase intracellular NAD⁺ levels which accelerates the activity of methyltransferase enzymes. This can create a significant demand for methyl groups and temporarily elevate homocysteine if methyl donors are insufficient. TMG serves as a methyl donor directly converting homocysteine back to methionine via the betaine-homocysteine methyltransferase pathway. Two capsules with breakfast provide exactly the 1–1.5 g range frequently cited in longevity-focused protocols. For anyone incorporating NMN, NR, or high-dose niacin into a longevity regimen, I consider TMG essential for maintaining methylation balance and minimizing potential homocysteine elevation. This particular TMG offering from Life Extension delivers reliable purity, potency, and value.

TMG by Life Extension is the best. I tried the powdered capsule from another brand and hated it. Something about the liquid capsule form and the quality of the product makes me feel better throughout the day. I would highly recommend you give this one a try!

TMG can be tough on the digestion in powder, tablets or powder capsules. This form is the best. It does not have any unhealthy additives and can be taken as one capsule twice daily or two at one time. I have tried other form and was glad I had tried this. I think the LE capsules are the perfect solution for people that find TriMethylGlycine or betaine harsh to digest. Without products like this one that are created by thinking "outside the box", many might avoid taking TMG. Yet TMG is so great for many, It supports methylation, liver health and SAMe production in the body. Would definitely recommend!!

I decided to give one to my very elderly mother thinking it would help her digestion. Little did I know that it would increase her appetite 3-fold! She is eating meat again too and drinking more water. Also, she's no longer saying depressing statements and is actually talking a little more often. I didn't expect such a major change from one pill. I hope this response continues for a long time and I thank the person who invented TMG along with the companies that sell it to the public. I would've gave this TMG product 5 stars had it not been for leaking capsules.

I’ve been taking **Life Extension NAD+ Cell Regenerator and Resveratrol Elite** for a few months and love the **boost in energy, mental clarity, and overall vitality**—thanks to its powerful blend of **Nicotinamide Riboside (Niagen®), Resveratrol, Quercetin, and Fisetin**. The formula supports **cellular repair, reduces oxidative stress, and promotes healthy aging**, making it a standout for longevity. While it’s a bit pricey, the high-quality, research-backed ingredients justify the cost. **Highly recommend for anyone focused on anti-aging and sustained energy! 5/5 stars.**

Great quality and fast delivery.

The last 5 bottles have had residue all over the capsules. Quality control is lacking. I’ve purchased this product 17 times, but will look elsewhere if I keep getting them with residue in them.

This has been a great addition alongside my methylated B vitamins. I take the TMG at night since it makes me a bit sleepy, and it feels like a supportive combo for overall restoration and balance. Clean formula and easy to incorporate into my routine.

Effective! My 4th or 5th bottle!

Las pildoras vienen mojadas y llenas de granitos. Parace que algunas de ellas explotaron y embarraron a las demás. No lo vuelvo a comprar

Great! Using to lower my Homocysteine levels!

The pill size is so large, that it is not comfortable to swallow (with water ofc).

Me encanta, buena relación precio/ calidad